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Blue Light‐Promoted N−H Insertion of Carbazoles, Pyrazoles and 1,2,3‐Triazoles into Aryldiazoacetates
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2020-01-16 , DOI: 10.1002/adsc.201901343
Mateus L. Stivanin 1 , Alessandra A. G. Fernandes 1 , Amanda F. Silva 1 , Celso Y. Okada 1 , Igor D. Jurberg 1
Affiliation  

Blue light irradiation of aryldiazoacetates leads to the formation of free carbenes, which can react with carbazoles, pyrazoles and 1,2,3‐triazoles to afford the corresponding N−H inserted products. These reactions are performed under air and at room temperature, allowing the mild preparation of a variety of motifs found in biologically relevant targets.

中文翻译:

蓝光促进将咔唑,吡唑和1,2,3-三唑插入N-H芳基重氮乙酸酯中

芳基重氮乙酸酯的蓝光照射导致形成游离的卡宾,这些卡宾可以与咔唑,吡唑和1,2,3-三唑反应,得到相应的NH插入产物。这些反应在空气和室温下进行,可以温和地制备生物学相关靶标中的各种基序。
更新日期:2020-01-17
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