Parkinson's disease (PD) is the most common neurodegenerative disease and is associated with a loss of dopaminergic neurons in the substantia nigra. Currently available treatments provide only symptomatic relief and there is no proper diagnosis tool to detect early stages of PD. Recently, nanomedicines and nanoformulation strategies have been widely adopted for the diagnosis and treatment of PD owing to their ability to improve treatment efficacy and provide unique diagnostic functions. Furthermore, advances in nanomedicine limit the potential side effects associated with conventional therapy and provide targeted drug delivery. The objective of this review is to discuss nanoformulation strategies used for the treatment as well as the diagnosis of PD.

中文翻译：

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不断发展的纳米制剂策略，用于帕金森氏病的诊断和临床干预。

帕金森氏病（PD）是最常见的神经退行性疾病，与黑质中多巴胺能神经元的丢失有关。当前可用的治疗仅提供症状缓解，并且没有适当的诊断工具来检测PD的早期阶段。近年来，由于纳米药物和纳米制剂具有提高治疗功效和提供独特诊断功能的能力，已被广泛用于PD的诊断和治疗。此外，纳米医学的进步限制了与常规疗法相关的潜在副作用，并提供了靶向药物递送。这篇综述的目的是讨论用于PD治疗和诊断的纳米制剂策略。