A silver-catalyzed hetero-dimerization of various vinyl isocyanides with isocyanoacetamides has been developed. This multistep domino reaction provides a facile protocol for the expedient synthesis of fully substituted pyridines in a single operation from readily available starting materials. An amidoketenimine and an azabutadienylketene are proposed as the key intermediates involved in this domino transformation. In addition, the resulting polysubstituted pyridines can be conveniently converted to pyridine-fused polycyclic frameworks.

中文翻译：

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银催化的异氰酸酯的化学选择性杂二聚反应，由多米诺合成全取代吡啶

已经开发了各种乙烯基异氰酸酯与异氰基乙酰胺的银催化的异二聚体。这种多步骤的多米诺骨牌反应提供了从容易获得的起始原料在一次操作中方便地合成完全取代的吡啶的简便方法。提出了氨基酮亚胺和氮杂丁二烯基酮作为参与该多米诺骨转化的关键中间体。另外，可以将所得的多取代的吡啶方便地转化为吡啶稠合的多环骨架。