Synthesis and complex self-assembly of amphiphilic block copolymers with a branched hydrophobic poly(2-oxazoline) into multicompartment micelles, pseudo-vesicles and yolk/shell nanoparticles,Polymer Chemistry

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Synthesis and complex self-assembly of amphiphilic block copolymers with a branched hydrophobic poly(2-oxazoline) into multicompartment micelles, pseudo-vesicles and yolk/shell nanoparticles
Polymer Chemistry ( IF 4.1 ) Pub Date : 2019/12/23 , DOI: 10.1039/c9py01559k
Davy Daubian _{1,

2,

3,

4} , Jens Gaitzsch _{1,

2,

3,

4,

5} , Wolfgang Meier _{1,

2,

3,

4}

Affiliation

We report on the synthesis and self-assembly of poly(ethylene oxide)-block-poly(2-(3-ethylheptyl)-2-oxazoline) (PEO-b-PEHOx), a new amphiphilic diblock copolymer obtained via microwave-assisted polymerization of EHOx using a new nosylated PEO macroinitiator. The kinetics of the polymerization in different solvents was crucial to optimize the synthesis and revealed a controlled, yet fast polymerization of the AB diblock copolymer. Differential scanning calorimetry proved that PEO-b-PEHOx shows glass transition temperatures below room temperature, making it suitable for a wide range of self-assembly methods, especially under mild and solvent-free conditions. Self-assembly of PEO-b-PEHOx was then performed using film rehydration and solvent switch. In both cases, we were able to show the formation of various complex structures (multi-compartment micelles (MCMs), pseudo-vesicles and yolk/shell nanoparticles) by light scattering, TEM and Cryo-TEM. Our results show that PEO-b-PEHOx is a potent new AB diblock copolymer due to its fast synthesis and unique self-assembly behavior.

中文翻译：

两性嵌段共聚物与支链疏水性聚（2-恶唑啉）的合成及其复杂的自组装，形成多室胶束，假囊泡和卵黄/壳纳米颗粒

我们的合成报告和聚（环氧乙烷）的自组装-嵌段-聚（2-（3-乙基庚基）-2-恶唑啉）（PEO- b -PEHOx），得到一个新的两亲性嵌段共聚物通过微波辅助使用新型的烷基化PEO大分子引发剂进行EHOx的聚合反应。在不同溶剂中聚合的动力学对于优化合成至关重要，并显示出AB二嵌段共聚物可控且快速的聚合。差示扫描量热法证明，PEO - b- PEHOx显示出低于室温的玻璃化转变温度，使其适用于多种自组装方法，尤其是在温和无溶剂的条件下。PEO- b的自组装然后使用膜水化和溶剂转换进行-PEHOx。在这两种情况下，我们都能够通过光散射，TEM和低温TEM证明各种复杂结构的形成（多室胶束（MCM），假囊泡和卵黄/壳纳米颗粒）。我们的结果表明，PEO- b -PEHOx由于其快速合成和独特的自组装行为而成为一种有效的新型AB二嵌段共聚物。

更新日期：2020-02-13

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