Multicomponent polymerization toward biodegradable polymers with diverse responsiveness in tumor microenvironments,Polymer Chemistry

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Multicomponent polymerization toward biodegradable polymers with diverse responsiveness in tumor microenvironments
Polymer Chemistry ( IF 4.1 ) Pub Date : 2019/12/23 , DOI: 10.1039/c9py01576k
Junnan He _{1,

2,

3,

4,

5} , Nan Zheng _{1,

2,

3,

4,

5} , Dan Xie _{1,

2,

3,

4,

5} , Yubin Zheng _{1,

2,

3,

4,

5} , Wangze Song _{1,

2,

3,

4,

5}

Affiliation

Multicomponent polymerization (MCP), as a powerful synthetic tool, has been widely utilized to prepare diverse functional polymers for optical, electronic, and biomedical applications. Here, a Cu(I)-catalyzed MCP toward biodegradable polymers with diverse responsiveness in tumor microenvironments (TMEs) is developed using diynes, sulfonyl azides and a series of TME-responsive, cleavable diols. The resulting polymers showed high molecular weights (up to 12000 g mol⁻¹) and high yields (up to 96%). The biodegradable polymers displayed excellent degradation performance in various simulated TMEs (reactive oxygen species, high reducing reagent, and low pH). One typical photosensitizer, tetraphenyl porphyrin (TPP), was conjugated to the side chains of the polymers for potential application in photodynamic therapy (PDT). The TPP-polymer conjugates displayed enhanced fluorescence intensity and higher singlet oxygen quantum yield than the TPP monomer due to the controlled conjugation efficiency and the unique MCP structure, which provided a complementary strategy to limit the undesired aggregation-caused-quenching (ACQ) effect of PDT.

中文翻译：

在肿瘤微环境中朝着具有多种响应性的可生物降解聚合物进行多组分聚合

作为一种强大的合成工具，多组分聚合（MCP）已被广泛用于制备用于光学，电子和生物医学应用的各种功能性聚合物。在这里，使用二炔，磺酰叠氮化物和一系列TME反应性可裂解的二醇，开发了Cu（I）催化的MCP，在肿瘤微环境（TME）中具有多种反应性的可生物降解的聚合物。所得聚合物显示出高分子量（高达12000 g mol ^-1）和高产量（高达96％）。可生物降解的聚合物在各种模拟的TME（活性氧，高还原剂和低pH）中均表现出出色的降解性能。一种典型的光敏剂四苯基卟啉（TPP）被偶联到聚合物的侧链上，可能在光动力疗法（PDT）中得到应用。TPP-聚合物共轭物显示出比TPP单体更高的荧光强度和更高的单线态氧量子产率，这归因于可控的共轭效率和独特的MCP结构，从而提供了一种补充策略来限制非期望的聚集引起的猝灭（ACQ）效应。太平洋夏令时。

更新日期：2020-02-13

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