Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac).,Organic & Biomolecular Chemistry

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Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac).
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9ob02433f
Harriet S Chidwick ₁ , Martin A Fascione ₁

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The non-mammalian nonulosonic acid sugar pseudaminic acid (Pse) is present on the surface of a number of human pathogens including Campylobacter jejuni and Helicobacter pylori and other bacteria such as multidrug resistant Acinetobacter baumannii. It is likely important for evasion of the host immune sysyem, and also plays a role in bacterial motility through flagellin glycosylation. Herein we review the mechanistic and structural characterisation of the enzymes responsible for the biosynthesis of the Pse parent structure, Pse5Ac7Ac in bacteria.

中文翻译：

机械和结构研究细菌糖伪氨基酸（Pse5Ac7Ac）的生物合成。

非哺乳动物的非牛磺酸糖伪氨基酸（Pse）存在于许多人类病原体的表面上，包括空肠弯曲菌和幽门螺杆菌以及其他细菌，例如耐多药鲍曼不动杆菌。这可能对逃避宿主免疫系统很重要，并且还通过鞭毛蛋白糖基化在细菌运动中发挥作用。本文中，我们综述了负责细菌中Pse亲本结构Pse5Ac7Ac生物合成的酶的机械结构特征。

更新日期：2020-02-13

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