Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing,Green Chemistry

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Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing
Green Chemistry ( IF 9.3 ) Pub Date : 2019/12/23 , DOI: 10.1039/c9gc03528a
Md Sadeque Hossain Mithu _{1,

2,

3,

4,

5} , Steven A. Ross _{1,

2,

3,

4,

5} , Bruce D. Alexander _{1,

2,

3,

4} , Dennis Douroumis _{1,

2,

3,

4,

6}

Affiliation

Thermomechanical engineering of pharmaceutical salts in the solid state using continuous extrusion processing (ssTME) is a new novel manufacturing approach. In the present work, we introduce a paradigm for the synthesis of ketoconazole – oxalic acid and ciprofloxacin – maleic acid salts by imparting temperature, shear rate and stress in comparison to liquid assisted grinding (LAG) approach. We demonstrated that thermomechanical synthesis is advantageous by producing high quality and pure, solvent-free pharmaceutical salts by tailoring extrusion processing variables.

中文翻译：

通过无溶剂连续处理对高品质药用盐进行固态热机械工程

使用连续挤压工艺（ssTME）对固态药物盐进行热机械工程设计是一种新的新颖制造方法。在当前的工作中，我们介绍了与液体辅助研磨（LAG）方法相比，通过赋予温度，剪切速率和应力来合成酮康唑–草酸和环丙沙星–马来酸盐的范例。我们证明了热机械合成通过调整挤出加工变量来生产高质量和纯净的，无溶剂的药用盐是有利的。

更新日期：2020-02-10

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