Programming nanoparticle valence bonds with single-stranded DNA encoders.,Nature Materials

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Programming nanoparticle valence bonds with single-stranded DNA encoders.
Nature Materials ( IF 37.2 ) Pub Date : 2019-12-23 , DOI: 10.1038/s41563-019-0549-3
Guangbao Yao _{1,

2} , Jiang Li _{2,

3} , Qian Li ₁ , Xiaoliang Chen ₂ , Xiaoguo Liu ₁ , Fei Wang ₁ , Zhibei Qu ₁ , Zhilei Ge ₁ , Raghu Pradeep Narayanan ₄ , Dewight Williams ₅ , Hao Pei ₆ , Xiaolei Zuo ₁ , Lihua Wang ₂ , Hao Yan ₄ , Ben L Feringa _{7,

8} , Chunhai Fan ₁

Affiliation

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Center for Molecular Design and Biomimetics, The Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
Erying Materials Center, Office of Knowledge Enterprise Development, Arizona State University, Tempe, AZ, USA.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.

Nature has evolved strategies to encode information within a single biopolymer to program biomolecular interactions with characteristic stoichiometry, orthogonality and reconfigurability. Nevertheless, synthetic approaches for programming molecular reactions or assembly generally rely on the use of multiple polymer chains (for example, patchy particles). Here we demonstrate a method for patterning colloidal gold nanoparticles with valence bond analogues using single-stranded DNA encoders containing polyadenine (polyA). By programming the order, length and sequence of each encoder with alternating polyA/non-polyA domains, we synthesize programmable atom-like nanoparticles (PANs) with n-valence that can be used to assemble a spectrum of low-coordination colloidal molecules with different composition, size, chirality and linearity. Moreover, by exploiting the reconfigurability of PANs, we demonstrate dynamic colloidal bond-breaking and bond-formation reactions, structural rearrangement and even the implementation of Boolean logic operations. This approach may be useful for generating responsive functional materials for distinct technological applications.

中文翻译：

用单链DNA编码器编程纳米粒子价键。

大自然已经发展出在单个生物聚合物中编码信息的策略，以编程具有特征化学计量，正交性和可重构性的生物分子相互作用。然而，用于编程分子反应或组装的合成方法通常依赖于使用多条聚合物链（例如，斑片状颗粒）。在这里，我们演示了一种使用含聚腺嘌呤（polyA）的单链DNA编码器用价键类似物构图胶体金纳米颗粒的方法。通过使用交替的polyA / non-polyA域对每个编码器的顺序，长度和序列进行编程，我们合成了具有n价的可编程原子状纳米粒子（PANs），可用于组装一系列具有不同价位的低配位胶体分子组成，大小，手性和线性。而且，通过利用PAN的可重构性，我们演示了动态胶体键断裂和键形成反应，结构重排甚至布尔逻辑运算的实现。该方法对于产生用于不同技术应用的响应性功能材料可能是有用的。

更新日期：2019-12-23

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