当前位置: X-MOL 学术Nat. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment.
Nature Immunology ( IF 27.7 ) Pub Date : 2019-12-23 , DOI: 10.1038/s41590-019-0561-4
Maria Esperanza Rodriguez-Ruiz 1, 2 , Ilio Vitale 3, 4 , Kevin J Harrington 5, 6 , Ignacio Melero 1, 2, 7, 8 , Lorenzo Galluzzi 9, 10, 11, 12, 13
Affiliation  

Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple, non-redundant mechanisms. Such mechanisms include the selective elimination of particularly radiosensitive cell types and consequent loss of specific cellular functions, the local release of cytokines and danger signals by dying radiosensitive cells, and altered cytokine secretion by surviving radioresistant cells. Altogether, these processes create chemotactic and immunomodulatory cues for incoming and resident immune cells. Here we discuss how cytoprotective and cytotoxic signaling modules activated by radiation in specific cell populations reshape the immunological tumor microenvironment.

中文翻译:


辐射驱动的细胞死亡信号对肿瘤微环境的免疫影响。



肿瘤微环境的治疗性照射会导致恶性细胞、基质细胞、内皮细胞和免疫细胞中促生存和促死亡途径的差异激活,从而通过多种非冗余机制引起深刻的细胞和生物重构。这些机制包括选择性消除特别对放射敏感的细胞类型并随后丧失特定的细胞功能、死亡的放射敏感细胞局部释放细胞因子和危险信号,以及存活的放射抗性细胞改变细胞因子的分泌。总而言之,这些过程为传入和驻留的免疫细胞创造了趋化和免疫调节信号。在这里,我们讨论特定细胞群中辐射激活的细胞保护和细胞毒性信号传导模块如何重塑免疫肿瘤微环境。
更新日期:2019-12-23
down
wechat
bug