AIM To study the incidence of glucose intolerance in CP patients without diabetes by performing oral glucose tolerance test (OGTT). METHODS We screened consecutive Indian CP patients without diabetes over 6 months by performing OGTT and correlated with physical characteristics and glycated hemoglobin (HbA1c). We also compared c-peptide and pancreatic polypeptide response in different groups based on OGTT. Relevant statistical tests were performed. P < 0.05 was considered significant. RESULTS Total of 171 patients were screened. Mean duration of CP was 5.03 ± 4.32 years. 55 were detected to have prediabetes and 40 DM on OGTT. CP patients with diabetes and prediabetes had significantly dilated pancreatic duct compared to non-diabetic CP (4.2 ± 2.7 mm, 3.6 ± 2.7 mm, 2.84 ± 2.25 mm; p = 0.018). Fasting blood glucose (FBS) and 2-hour OGTT were 109.35 ± 19.06, 97.47 ± 11.94, 85.24 ± 9.95 and 236.13 ± 31.42, 154.65 ± 19.53, 112.89 ± 16.32 in patients with DM, prediabetes and CP patients without diabetes (p < 0.0001). There was a good c-peptide response (p = 0.001) and reduced pancreatic polypeptide response (p = 0.003) in CP patients compared to controls. CONCLUSION Early in the course of disease reduced pancreatic polypeptide response in the presence of good c-peptide response may result in development of DM.

中文翻译：

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胰腺多肽应答降低与慢性胰腺炎中血糖控制的早期改变有关。

目的通过进行口服葡萄糖耐量试验（OGTT）研究无糖尿病CP患者的葡萄糖耐量异常情况。方法我们通过进行OGTT筛选连续6个月以上无糖尿病的印度CP患者，并将其与身体特征和糖化血红蛋白（HbA1c）相关。我们还比较了基于OGTT的不同组中c肽和胰腺多肽的反应。进行了相关的统计检验。P <0.05被认为是显着的。结果共筛选了171例患者。CP的平均持续时间为5.03±4。32年。在OGTT上检测到55例患有糖尿病前期和40 DM。与非糖尿病CP相比，患有糖尿病和糖尿病前期的CP患者的胰管显着扩张（4.2±2.7 mm，3.6±2.7 mm，2.84±2.25 mm； p = 0.018）。空腹血糖（FBS）和2小时OGTT为109。DM，糖尿病前期和非糖尿病CP患者的35±19.06、97.47±11.94、85.24±9.95和236.13±31.42、154.65±19.53、112.89±16.32（p <0.0001）。与对照组相比，CP患者的c肽应答良好（p = 0.001），胰多肽应答降低（p = 0.003）。结论在疾病早期，在良好的c肽反应下，胰腺多肽反应降低可能导致DM的发展。