This paper is written for non-specialists in mitochondrial biology to provide access to an important area of science that has broad implications for all people. The cell danger response (CDR) is a universal response to environmental threat or injury. Once triggered, healing cannot be completed until the choreographed stages of the CDR are returned to an updated state of readiness. Although the CDR is a cellular response, it has the power to change human thought and behavior, child development, physical fitness and resilience, fertility, and the susceptibility of entire populations to disease. Mitochondria regulate the CDR by monitoring and responding to the physical, chemical, and microbial conditions within and around the cell. In this way, mitochondria connect cellular health to environmental health. Over 7,000 chemicals are now made or imported to the US for industrial, agricultural, and personal care use in amounts ranging from 25,000 to over 1 million pounds each year, and plastic waste now exceeds 83 billion pounds/year. This chemical load creates a rising tide of manmade pollutants in the oceans, air, water, and food chain. Fewer than 5% of these chemicals have been tested for developmental toxicity. In the 1980s, 5-10% of children lived with a chronic illness. As of 2018, 40% of children, 50% of teens, 60% of adults under age 65, and 90% of adults over 65 live with chronic illness. Several studies now report the presence of dozens to hundreds of manmade chemicals and pollutants in placenta, umbilical cord blood, and newborn blood spots. New methods in metabolomics and exposomics allow scientists to measure thousands of chemicals in blood, air, water, soil, and the food chain. Systematic measurements of environmental chemicals can now be correlated with annual and regional patterns of childhood illness. These data can be used to prepare a prioritized list of molecules for congressional action, ranked according to their impact on human health. "When a deep injury is done to us, we never heal until we forgive." --Nelson Mandela (1918-2013).

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观点：细胞危险反应生物学——将环境健康与线粒体和慢性疾病的上升联系起来的新科学

这篇论文是为非线粒体生物学专家编写的，目的是让他们能够接触到一个对所有人都有广泛影响的重要科学领域。细胞危险反应 (CDR) 是对环境威胁或伤害的普遍反应。一旦触发，在 CDR 的编排阶段返回到更新的准备状态之前，无法完成愈合。虽然 CDR 是一种细胞反应，但它有能力改变人类的思想和行为、儿童发展、身体健康和弹性、生育能力以及整个人群对疾病的易感性。线粒体通过监测和响应细胞内和细胞周围的物理、化学和微生物条件来调节 CDR。通过这种方式，线粒体将细胞健康与环境健康联系起来。7岁以上，000 化学品现在被制造或进口到美国用于工业、农业和个人护理用途，每年的数量从 25,000 磅到超过 100 万磅不等，塑料废物现在超过 830 亿磅/年。这种化学负荷在海洋、空气、水和食物链中造成了人造污染物的上升潮。这些化学品中只有不到 5% 已经过发育毒性测试。在 1980 年代，5-10% 的儿童患有慢性疾病。截至 2018 年，40% 的儿童、50% 的青少年、60% 的 65 岁以下成年人和 90% 的 65 岁以上成年人患有慢性疾病。现在有几项研究报告称，胎盘、脐带血和新生儿血斑中存在数十至数百种人造化学物质和污染物。代谢组学和暴露组学的新方法使科学家能够测量血液、空气、水、土壤和食物链。环境化学物质的系统测量现在可以与儿童疾病的年度和区域模式相关联。这些数据可用于为国会行动准备分子的优先列表，根据它们对人类健康的影响进行排名。“当我们受到深深的伤害时，除非我们原谅，否则我们永远不会痊愈。” ——纳尔逊·曼德拉（1918-2013）。