Context-dependent representations of objects and space in the primate hippocampus during virtual navigation.,Nature Neuroscience

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Context-dependent representations of objects and space in the primate hippocampus during virtual navigation.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-12-23 , DOI: 10.1038/s41593-019-0548-3
Roberto A Gulli _{1,

2,

3,

4} , Lyndon R Duong _{2,

5} , Benjamin W Corrigan _{1,

2} , Guillaume Doucet _{2,

6,

7} , Sylvain Williams ₈ , Stefano Fusi _{3,

4,

9} , Julio C Martinez-Trujillo _{2,

10,

11}

Affiliation

Integrated Program in Neuroscience, McGill University, Montréal, Quebec, Canada.
Robarts Research Institute, Western University, London, Ontario, Canada.
Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Center for Theoretical Neuroscience, Columbia University, New York, NY, USA.
Center for Neural Science, New York University, New York, NY, USA.
Department of Physiology, McGill University, Montréal, Quebec, Canada.
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Department of Psychiatry, Douglas Research Center, McGill University, Montréal, Quebec, Canada.
Kavli Institute for Brain Sciences, Columbia University, New York, NY, USA.
Brain & Mind Institute, Western University, London, Ontario, Canada.
Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

The hippocampus is implicated in associative memory and spatial navigation. To investigate how these functions are mixed in the hippocampus, we recorded from single hippocampal neurons in macaque monkeys navigating a virtual maze during a foraging task and a context-object associative memory task. During both tasks, single neurons encoded information about spatial position; a linear classifier also decoded position. However, the population code for space did not generalize across tasks, particularly where stimuli relevant to the associative memory task appeared. Single-neuron and population-level analyses revealed that cross-task changes were due to selectivity for nonspatial features of the associative memory task when they were visually available (perceptual coding) and following their disappearance (mnemonic coding). Our results show that neurons in the primate hippocampus nonlinearly mix information about space and nonspatial elements of the environment in a task-dependent manner; this efficient code flexibly represents unique perceptual experiences and correspondent memories.

中文翻译：

虚拟导航期间灵长类海马中物体和空间的上下文相关表示。

海马体与联想记忆和空间导航有关。为了研究这些功能如何在海马体中混合，我们记录了猕猴在觅食任务和上下文对象联想记忆任务期间导航虚拟迷宫的单个海马神经元。在这两项任务中，单个神经元编码了有关空间位置的信息。一个线性分类器也解码了位置。然而，空间的总体代码并没有在任务中推广，特别是在与联想记忆任务相关的刺激出现的情况下。单神经元和群体水平分析表明，跨任务变化是由于联想记忆任务的非空间特征在视觉上可用（感知编码）和消失后（记忆编码）的选择性。我们的研究结果表明，灵长类海马体中的神经元以任务依赖的方式非线性地混合有关环境的空间和非空间元素的信息；这种高效的代码灵活地代表了独特的感知体验和对应的记忆。

更新日期：2019-12-23

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