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Biosynthetic Pathways to Nonproteinogenic α-Amino Acids.
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-12-23 , DOI: 10.1021/acs.chemrev.9b00408
Jason B Hedges 1 , Katherine S Ryan 1
Affiliation  

Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic amino acids. Such amino acids are generated in specialized metabolic pathways. In these pathways, diverse biosynthetic transformations, ranging from isomerizations to the stereospecific functionalization of C-H bonds, are employed to generate structural diversity. The resulting nonproteinogenic amino acids can be integrated into more complex natural products. Here we review recently discovered biosynthetic routes to freestanding nonproteinogenic α-amino acids, with an emphasis on work reported between 2013 and mid-2019.

中文翻译:

非蛋白源性α-氨基酸的生物合成途径。

天然的非蛋白质氨基酸大大超过了众所周知的22种蛋白质氨基酸。这些氨基酸是在专门的代谢途径中产生的。在这些途径中,采用各种生物合成转化,从异构化到CH键的立体特异性官能化,以产生结构多样性。所得的非蛋白氨基酸可整合到更复杂的天然产物中。在这里,我们回顾了最近发现的独立于非蛋白原性α-氨基酸的生物合成途径,重点是2013年至2019年中期报告的工作。
更新日期:2019-12-23
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