Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities.,Journal of Natural Products

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Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2019-12-20 , DOI: 10.1021/acs.jnatprod.9b00849
Achara Raksat , Piyaporn Phukhatmuen , Jianxiong Yang , Wisanu Maneerat , Rawiwan Charoensup , Raymond J Andersen , Yan A Wang , Stephen G Pyne ₁ , Surat Laphookhieo

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Five new compounds-two phloroglucinol benzophenones, garciniacowones F (1) and G (2), and three xanthones, garciniacowones H (3), I (4), and J (5)-together with seven known xanthones (6-12) were isolated from the fresh leaves of Garcinia cowa. Their structures were elucidated by detailed analysis of NMR and MS data. Compounds 1 and 2 are phloroglucinol benzophenones containing a polyprenylated bicyclo[3.3.1]nonane ring system, while compounds 3-5 are rare xanthones having farnesyl (3 and 5) and geranylgeranyl (5) units at C-8. Compounds 1, 3, 4, 7, 8, and 10 exhibited inhibitory effects on NO production in LPS-induced RAW264.7 macrophage cells with IC50 values ranging from 5.4 to 18.6 μM. Compounds 4 and 8 had α-glucosidase inhibitory activities with IC50 values of 15.4 and 11.4 μM, respectively, which were more potent than that of the acarbose control.

中文翻译：

藤黄叶中的间苯三酚二苯甲酮和黄原酮及其一氧化氮的产生和α-葡萄糖苷酶的抑制活性。

五个新化合物-两个间苯三酚二苯甲酮，藤黄酮F（1）和G（2）和三个氧杂蒽酮，藤黄酮H（3），I（4）和J（5）-与七个已知的黄原酮（6-12）一起从藤黄的新鲜叶子中分离得到。通过对NMR和MS数据进行详细分析，阐明了它们的结构。化合物1和2是间苯三酚二苯甲酮，其中含有多异戊二烯基双环[3.3.1]壬烷环系统，而化合物3-5是在C-8处具有法尼基（3和5）和香叶基香叶基（5）的稀有x吨。在LPS诱导的RAW264.7巨噬细胞中，化合物1、3、4、7、8和10表现出对NO产生的抑制作用，IC50值为5.4至18.6μM。化合物4和8具有α-葡萄糖苷酶抑制活性，IC50值分别为15.4和11.4μM，

更新日期：2019-12-21

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