We read the article by Wade et al 1 with great interest. With very elegant experiments, they have reported enrichment of polyfunctional T-lymphocytes in the synovial tissue of psoriatic arthritis (PsA); they have also noticed that polyfunctional synovial T-cells were positively associated with Disease Activity Index for Psoriatic Arthritis. We agree there are only limited studies in human autoimmune diseases which have addressed regulatory role of T-cell polyfunctionality of the activated effector memory T cells (TEM) in single cell suspensions. We have been working on TEM cell subpopulations in PsA and over years have demonstrated Th17, Th9 and mucosal-associated invariant T cells in PsA,2–4 which are also polyfunctional. In respect to studying polyfunctional T cells in PsA instead of focusing on Th1, Th17 and exTh17 cells,1 we took a different approach to look into the cytokine profile and polyclonality of these TEM cells in respect their profound role in the disease process of PsA such as (IL-17, IL-23R, IL-22 and TNFα) and also compared with that polyfunctional T cells of rheumatoid arthritis (RA) to see whether a role of polyfunctional T cells can be reproduced in an another autoimmune arthritis and if so to identify the differences …

中文翻译：

---

银屑病关节炎滑膜中的多功能 TEM 细胞偏向 Th17 细胞

我们怀着极大的兴趣阅读了 Wade 等人 1 的文章。通过非常优雅的实验，他们报告了银屑病关节炎（PsA）滑膜组织中多功能 T 淋巴细胞的富集；他们还注意到多功能滑膜 T 细胞与银屑病关节炎的疾病活动指数呈正相关。我们同意在人类自身免疫性疾病中只有有限的研究解决了单细胞悬液中激活的效应记忆 T 细胞 (TEM) 的 T 细胞多功能性的调节作用。我们一直在研究 PsA 中的 TEM 细胞亚群，多年来已经证明 PsA 中的 Th17、Th9 和粘膜相关不变 T 细胞，2-4 也是多功能的。关于研究 PsA 中的多功能 T 细胞，而不是专注于 Th1、Th17 和 exTh17 细胞，