The transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis. Aberrant activation of E2F1 is closely associated with a poor clinical outcome in various human cancers. However, E2F1 has conflictingly been reported to exert tumor suppressive activity, raising a question as to the nature of its substantive role in the control of cell fate. In this review, we summarize deregulated E2F1 activity and its role in prostate cancer. We highlight the recent advances in understanding the molecular mechanism by which E2F1 regulates the development and progression of prostate cancer, providing insight into how cell context or data interpretation shapes the role of E2F1 in prostate cancer. This review will aid in translating biomedical knowledge into therapeutic strategies for prostate cancer.

中文翻译：

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E2F1在前列腺癌中的冲突作用：细胞情况还是解释灵活性？

转录因子E2F1在介导调节细胞周期，存活，凋亡，代谢和转移的多种癌症标志功能中起着至关重要的作用。E2F1的异常激活与各种人类癌症的不良临床结果密切相关。然而，据报道，E2F1发挥了抑癌作用，这在其对细胞命运的控制中起实质性作用的性质提出了一个疑问。在这篇综述中，我们总结了放松的E2F1活性及其在前列腺癌中的作用。我们强调了解E2F1调节前列腺癌的发展和进程的分子机制的最新进展，从而深入了解细胞背景或数据解释如何塑造E2F1在前列腺癌中的作用。