Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establish cell polarization. In this review, we discuss the current understanding of cell polarity establishment, focusing on the formation of the apical domain in the mouse embryo. We will also discuss outstanding questions and possible directions for future study.

中文翻译：

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在早期小鼠胚胎中构建顶端域：教训、挑战和观点。

细胞极化对于哺乳动物胚胎发生过程中的谱系分离和形态发生至关重要。然而，在哺乳动物胚胎中建立细胞极性的过程和机制尚不清楚。最近的研究表明，小鼠胚胎利用独特的调节机制来建立细胞极化。在这篇综述中，我们讨论了目前对细胞极性建立的理解，重点关注小鼠胚胎中顶端域的形成。我们还将讨论突出的问题和未来研究的可能方向。