Tazarotene (TZR) is the first topical receptor-selective retinoid prodrug derived from vitamin A used for management of plaque psoriasis and efficacious in dealing of acne vulgaris, and photo aging. As per US food and drug administration (FDA), 0.1% strength of TZR is permitted for the treatment of acne. This article draws attention to various advanced and conventional analytical methods. The hyphenated and conventional chromatographic techniques such as LC-MS/MS and HPTLC, HPLC respectively. Moreover, spectrophotometric methods like UV/visible spectroscopy also used to quantify TZR as active pharmaceutical ingredient and its formulations, especially in topical preparations. Moreover, the TZR is required alternative methods for routine quality control and to estimate TZR in pharmaceutical dosage form especially in pharmacokinetic studies of topical preparation. This write up focus on critical review of characteristics, uses and the information about the physicochemical, pharmacokinetics properties, mechanisms of action and more emphasis on different analytical methods for estimation of TZR in pharmaceutical formulations.

中文翻译：

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他扎罗汀的特征和分析方法综述：最新进展。

他扎罗汀（TZR）是第一种从维生素A衍生出来的局部受体选择性类维生素A前药，用于治疗斑块状牛皮癣，有效治疗寻常痤疮和光老化。根据美国食品药品监督管理局（FDA）的规定，允许0.1％的TZR强度用于治疗痤疮。本文引起人们对各种先进和常规分析方法的关注。联用和常规色谱技术分别为LC-MS / MS和HPTLC，HPLC。此外，分光光度法（例如紫外/可见光谱法）也用于定量测定作为活性药物成分及其制剂的TZR，特别是在局部制剂中。而且，TZR是常规质量控制和评估药物剂型中TZR所需要的替代方法，尤其是在局部制剂的药代动力学研究中。本文着重于对特性，用途和有关理化，药代动力学特性，作用机理的信息进行严格审查，并更加侧重于估算药物制剂中TZR的不同分析方法。