High alcohol consumption and physical inactivity are known breast cancer risk factors. However, whether the association between these lifestyle factors and breast cancer is modified by a woman's additional breast cancer risk factors has never been studied. Therefore, a population‐based prospective cohort study of 57,654 Swedish women aged 40–74 years, including 957 breast cancer cases, was performed. Alcohol consumption and physical activity were measured with validated web‐based self‐report questionnaires. The Tyrer–Cuzick risk prediction model was used to determine a woman's 10‐year risk of developing breast cancer. Logistic regression models were used to explore whether the effect of alcohol consumption and physical activity on breast cancer was modified by additional breast cancer risk factors. Findings showed that increased alcohol consumption was associated with a higher breast cancer risk (OR = 1.26, 95% CI 1.01, 1.59). However, the association between lifestyle factors (alcohol consumption and physical activity) and breast cancer was generally the same for women at below average, average and above average risk of developing breast cancer. Therefore, additional breast cancer risk factors do not appear to modify the association between lifestyle (alcohol consumption and physical activity) and breast cancer. Considering the general health benefits, preventative lifestyle recommendations can be formulated about alcohol consumption and physical activity for women at all levels of breast cancer risk.

中文翻译：

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饮酒和体育锻炼对乳腺癌的影响：乳腺癌风险的作用。

高饮酒和缺乏运动是已知的乳腺癌危险因素。然而，从未研究过这些生活方式因素与乳腺癌之间的关联是否被女性的其他乳腺癌危险因素所改变。因此，进行了一项基于人群的前瞻性队列研究，研究对象为57,654名40-74岁的瑞典妇女，包括957名乳腺癌患者。酒精摄入量和身体活动量通过经过验证的基于网络的自我报告调查表进行测量。Tyrer-Cuzick风险预测模型用于确定女性患乳腺癌的10年风险。使用Logistic回归模型探讨饮酒和体育锻炼对乳腺癌的影响是否被其他乳腺癌危险因素所修正。研究结果表明，饮酒增加与较高的乳腺癌风险相关（OR = 1.26，95％CI 1.01，1.59）。然而，生活方式因素（饮酒和体育锻炼）与乳腺癌之间的相关性通常对于处于罹患乳腺癌的风险低于平均水平，平均水平和高于平均水平的女性而言是相同的。因此，其他乳腺癌危险因素似乎并未改变生活方式（饮酒和体育锻炼）与乳腺癌之间的关联。考虑到一般健康益处，可以针对妇女在各种乳腺癌风险水平下的饮酒量和体育锻炼制定预防性生活方式建议。妇女的生活方式因素（饮酒和体育锻炼）与乳腺癌之间的关联通常相同，处于罹患乳腺癌的风险低于平均水平，平均水平和高于平均水平的女性。因此，其他乳腺癌危险因素似乎并未改变生活方式（饮酒和体育锻炼）与乳腺癌之间的关联。考虑到一般健康益处，可以针对妇女在各种乳腺癌风险水平下的饮酒量和体育锻炼制定预防性生活方式建议。妇女的生活方式因素（饮酒和体育锻炼）与乳腺癌之间的关联通常相同，处于罹患乳腺癌的风险低于平均水平，平均水平和高于平均水平的女性。因此，其他乳腺癌危险因素似乎并未改变生活方式（饮酒和体育锻炼）与乳腺癌之间的关联。考虑到一般健康益处，可以针对妇女在各种乳腺癌风险水平下的饮酒量和体育锻炼制定预防性生活方式建议。其他乳腺癌危险因素似乎并未改变生活方式（饮酒和体育锻炼）与乳腺癌之间的关联。考虑到一般健康益处，可以针对妇女在各种乳腺癌风险水平下的饮酒量和体育锻炼制定预防性生活方式建议。其他乳腺癌危险因素似乎并未改变生活方式（饮酒和体育锻炼）与乳腺癌之间的关联。考虑到一般健康益处，可以针对妇女在各种乳腺癌风险水平下的饮酒量和体育锻炼制定预防性生活方式建议。