Younger age at diagnosis often reflects a greater influence of genetic factors in disease. Type 1 diabetes, which develops most frequently in childhood but can also present in adult life, is a prime candidate to explore the relationships among risk loci, age at diagnosis, and genetic contribution to disease. Type 1 diabetes genetic risk scores (GRS) (calculated as the weighted sum of alleles statistically associated with type 1 diabetes present in a given individual) are inversely correlated with age at diagnosis. Studies have suggested age-related heterogeneity in the association of established risk alleles with type 1 diabetes, although no consistent pattern has developed. Further investigations into the genetic factors that influence age of clinical onset may refine our understanding of type 1 diabetes pathogenesis and provide opportunities for individualized preventive therapies.

中文翻译：

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1型糖尿病的遗传学随着年龄的增长而变化。

诊断时年龄较小常反映出遗传因素对疾病的更大影响。1型糖尿病是儿童时期最常见的疾病，但也可能存在于成年人中，是探讨危险基因位点，诊断年龄和疾病遗传因素之间关系的主要候选对象。1型糖尿病的遗传风险评分（GRS）（以与给定个体中存在的1型糖尿病统计相关的等位基因的加权总和计算）与诊断时的年龄呈负相关。研究表明，虽然尚未形成一致的模式，但已建立的风险等位基因与1型糖尿病的关联存在与年龄相关的异质性。