A 63-year-old woman presented with bilateral lower extremity weakness, Lhermitte sign, and urinary retention over a 3-week period. She had a 35–pack-year smoking history and was diagnosed as having stage IV small-cell lung cancer with lymphatic and liver metastases. She had been treated with 3 cycles of etoposide and carboplatin (3 daily doses per cycle) and atezolizumab (humanized monoclonal IgG1 antibody against programmed cell death ligand 1 [PDL1]; 1 dose per cycle).

Examination demonstrated bilateral finger extensor weakness, lower limb pyramidal weakness greater on the right side, bilateral Babinski signs, reduced vibration, joint position sense, and a midchest pin-prick sensory level. At the nadir, she required a wheelchair and self-catheterization.

一名63岁的妇女在3周的时间内出现双侧下肢无力，Lhermitte征象和尿retention留。她有35年的吸烟史，被诊断为患有淋巴和肝转移的IV期小细胞肺癌。她接受了3个周期的依托泊苷和卡铂（每个周期3次日剂量）和atezolizumab（针对程序化细胞死亡配体1 [PDL1]的人源化单克隆IgG1抗体；每个周期1剂）的治疗。

检查显示双侧手指伸肌无力，右侧下肢锥体无力更大，双侧Babinski体征，振动减轻，关节位置感降低，胸中针刺感觉水平降低。在最低点，她需要轮椅和自我导尿。