The mammalian circadian clock precisely controls various physiological processes, including energy metabolism, to help body adapt to the diurnal light/dark cycles induced by the earth autorotation. Although the clock and metabolism are tightly coupled and interacted, the molecular mechanism through which these two pathways are integrated remains largely unknown. In the past 10 years, we have been focusing on this important scientific question and innovatively proposed three integration modes, including the "parallel connection" mode orchestrated by nuclear factors, the "serial connection" mode orchestrated by clock-controlled proteins, and the "combinational connection" mode regulated by metabolites. Here we summarize and discuss the molecular mechanisms of the integration between peripheral circadian clock and energy metabolism in metabolic tissues.

中文翻译：

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代谢组织中外周生物钟和能量代谢的整合。

哺乳动物的生物钟精确控制包括能量代谢在内的各种生理过程，帮助身体适应地球自转引起的昼夜光暗循环。尽管生物钟和新陈代谢紧密耦合和相互作用，但这两种途径整合的分子机制在很大程度上仍是未知的。10年来，我们围绕这一重大科学问题，创新性地提出了三种整合模式，包括由核因子协调的“平行连接”模式、由时钟控制的蛋白质协调的“串联”模式以及“代谢物调控的“组合连接”模式。