In this paper, a type of phycocyanin (PC)-functionalized and curcumin (CUR)-loaded biotin-chitosan oligosaccharide-dithiodipropionic acid-curcumin (BCSC) nanoparticles, called CUR-BCSC@PCs, were designed to enhance the biocompatibility of CUR. The structure of BCSC was confirmed using 1H-NMR. In CUR-BCSC@PCs with an average hydrodynamic diameter of 160.3 ± 9.0 nm, the biomimetic protein corona gave the nanoparticles excellent stability and the potential to avoid protein adsorption in blood circulation. The in vitro release experiment verified that CUR-BCSC@PCs with redox responsive shells were sensitive to high concentrations of glutathione. In addition, CUR-BCSC@PCs were effective at increasing the inhibitory activity on the proliferation of A549 cells by enhancing the intracellular uptake of CUR. These results indicated that CUR-BCSC@PCs have great application prospects in cancer therapy as effective drug delivery carriers.

中文翻译：

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藻蓝蛋白包覆的氧化还原敏感性壳聚糖寡糖纳米粒子的合成，表征和评价。

本文设计了一种负载藻蓝蛋白（PC）的功能化和姜黄素（CUR）负载的生物素-壳聚糖寡糖-二硫代二丙酸-姜黄素（BCSC）纳米颗粒，以增强CUR的生物相容性。BCSC的结构使用1 H-NMR确认。在平均流体动力学直径为160.3±9.0 nm的CUR-BCSC @ PC中，仿生蛋白质电晕使纳米粒子具有出色的稳定性，并有可能避免蛋白质在血液循环中的吸附。体外释放实验证明，具有氧化还原反应壳的CUR-BCSC @ PC对高浓度的谷胱甘肽敏感。此外，CUR-BCSC @ PCs通过增强细胞内CUR的摄取，有效提高了对A549细胞增殖的抑制活性。