BACKGROUND Increasing studies have focused on motor function/dysfunction in PICU survivors; however, most studies have focused on adults and older children. This study investigated gross motor developmental function outcomes in infantile and toddler pediatric intensive care unit (PICU) survivors and the factors associated with gross motor developmental functions. METHODS This observational study was conducted in the PICU of the First Hospital of Jilin University between January 2019 and March 2019. Thirty-five eligible patients were divided into the dysfunctional (n = 24) or non-dysfunctional (n = 11) group according to the results of the Peabody Developmental Motor Scales, Second Edition (PDMS-2). Baseline gross motor function for all participants before PICU admission was measured via the Age and Stages Questionnaires, Third Edition (ASQ-3). The PDMS-2 was used to evaluate gross motor development function before PICU discharge. RESULTS The gross motor developmental dysfunction incidence was 68.6%. Linear correlation analysis showed that the gross motor quotient (GMQ) was positively correlated with the pediatric critical illness score (PCIS, r = 0.621, P < 0.001), and negatively correlated with length of PICU stay (r = - 0.556, P = 0.001), days sedated (r = - 0.602, P < 0.001), days on invasive mechanical ventilation (IMV; r = - 0.686, P < 0.001), and days on continuous renal replacement therapy (CRRT; r = - 0.538, P = 0.001). Linear regression analysis showed that IMV days (β = - 0.736, P = 0.001), sepsis (β = - 18.111, P = 0.003) and PCIS (β = 0.550, P = 0.021) were independent risk factors for gross motor developmental dysfunction. CONCLUSIONS Gross motor developmental dysfunction in infantile and toddler PICU survivors is more common and may be exacerbated by experiences associated with longer IMV days and increasing illness severity combined with sepsis. TRIAL REGISTRATION The trial 'Early rehabilitation intervention for critically ill children' has been registered at http://www.chictr.org.cn/showproj.aspx?proj=23132. Registration number: ChiCTR1800020196.

中文翻译：

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婴幼儿重症监护病房幸存者的总体运动发育功能障碍。

背景技术越来越多的研究集中在PICU幸存者的运动功能/功能障碍。但是，大多数研究都集中在成年人和年龄较大的儿童上。这项研究调查了婴幼儿重症监护病房（PICU）幸存者的总体运动发育功能结局以及与总体运动发育功能相关的因素。方法这项观察性研究于2019年1月至2019年3月在吉林大学第一医院PICU进行。根据研究，将35例符合条件的患者分为功能障碍（n = 24）或非功能障碍（n = 11）组。皮博迪发育运动量表第二版（PDMS-2）的结果。通过年龄和阶段问卷，第3版（ASQ-3）测量了入入PICU之前所有参与者的基线总运动功能。PDMS-2用于评估PICU放电前的总体运动发育功能。结果运动发育障碍的总发生率为68.6％。线性相关分析表明，运动总商数（GMQ）与小儿危重病评分（PCIS，r = 0.621，P <0.001）正相关，与PICU住院时间呈负相关（r =-0.556，P = 0.001） ），镇静天数（r =-0.602，P <0.001），有创机械通气天数（IMV; r =-0.686，P <0.001）和连续肾脏替代治疗的天数（CRRT; r =-0.538，P = 0.001）。线性回归分析显示，IMV天数（β=-0.736，P = 0.001），败血症（β=-18.111，P = 0.003）和PCIS（β= 0.550，P = 0.021）是严重运动发育障碍的独立危险因素。结论在婴儿和学步PICU幸存者中，严重的运动发育障碍更为普​​遍，与更长的IMV天数，疾病严重程度增加以及败血症相关的经验可能会加剧这种疾病。试验注册“重症儿童早期康复干预”试验已在http://www.chictr.org.cn/showproj.aspx?proj=23132上注册。注册号：ChiCTR1800020196。