BACKGROUND Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Due to increased CAD risk factors in Saudi Arabia, research on more feasible and predictive biomarkers is needed. We aimed to evaluate glycated hemoglobin (HbA1c) as a predictor of CAD in low-risk profile non-diabetic patients living in the Al Qassim region of Saudi Arabia. METHODS Thirty-eight patients with no history of CAD were enrolled in this cross-sectional study. They provided demographic data, and their HbA1c estimation followed the National Glycohemoglobin Standardization Program parameters. All patients underwent coronary computed tomography angiography (CCTA) for evaluation of chest pain. The extent of coronary artery stenosis (CAS) was quantified as percentage for each patient based on plaques detected in CCTA. RESULTS Mean blood pressure of the patients was (91.2 ± 11.9 mmHg), BMI (28.3 ± 5.8 kg/m2), serum cholesterol level (174 ± 33.1 mg/dl), and HbA1c levels (mean 5.7 ± 0.45, median 5.7 and range 4.7-6.4%). Eighteen patients showed no CAS (47.4%), 12 showed minimal stenosis (31.6%), 3 showed mild stenosis (7.9%), 3 showed moderate stenosis (7.9%) and 2 showed severe stenosis (5.3%). A moderate correlation was detected between HbA1c and CAS percentages (r = 0.47, p < 0.05) as well as between HbA1c and the number of affected coronary vessels (r = 0.53, p < 0.001). CONCLUSION Glycated hemoglobin can be used as a predictive biomarker for CAD in non-diabetic low-risk patients.

中文翻译：

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糖化血红蛋白可预测非糖尿病成人的冠状动脉疾病。

背景技术冠状动脉疾病(CAD)是全世界发病和死亡的主要原因。由于沙特阿拉伯 CAD 风险因素增加，需要研究更可行和更具预测性的生物标志物。我们的目的是评估糖化血红蛋白 (HbA1c) 作为生活在沙特阿拉伯 Al Qassim 地区的低风险非糖尿病患者 CAD 的预测因子。方法 38 名无 CAD 病史的患者参与了这项横断面研究。他们提供了人口统计数据，其 HbA1c 估算遵循国家糖化血红蛋白标准化计划参数。所有患者均接受冠状动脉计算机断层扫描血管造影（CCTA）以评估胸痛。根据 CCTA 中检测到的斑块，将每位患者的冠状动脉狭窄 (CAS) 程度量化为百分比。结果 患者的平均血压为（91.2 ± 11.9 mmHg），BMI（28.3 ± 5.8 kg/m2），血清胆固醇水平（174 ± 33.1 mg/dl）和 HbA1c 水平（平均值 5.7 ± 0.45，中位数 5.7 和范围） 4.7-6.4%）。18 例患者无 CAS (47.4%)，12 例显示轻微狭窄 (31.6%)，3 例显示轻度狭窄 (7.9%)，3 例显示中度狭窄 (7.9%)，2 例显示重度狭窄 (5.3%)。在 HbA1c 和 CAS 百分比之间（r = 0.47，p < 0.05）以及 HbA1c 和受影响的冠状血管数量之间（r = 0.53，p < 0.001）检测到中等相关性。结论 糖化血红蛋白可作为非糖尿病低危患者 CAD 的预测生物标志物。