A Magnetic Drug Delivery System with "OFF-ON" State via Specific Molecular Recognition and Conformational Changes for Precise Tumor Therapy.,Advanced Healthcare Materials

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A Magnetic Drug Delivery System with "OFF-ON" State via Specific Molecular Recognition and Conformational Changes for Precise Tumor Therapy.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-12-19 , DOI: 10.1002/adhm.201901316
Junjie Liu _{1,

2,

3} , Wei Liu _{1,

2,

3} , Kaixiang Zhang _{1,

2,

3} , Jinjin Shi _{1,

2,

3} , Zhenzhong Zhang _{1,

2,

3}

Affiliation

To enhance the tumor-targeting and tumor cell-specific drug-release capacity of nano drug delivery systems, a magnetic resonance imaging-traceable, magnetic-targeted nanoplatform is developed, and the nanoplatform is prepared by capping mesoporous silica (MSN)-coated iron oxide nanoparticles (IONPs) with programmable DNA hairpin sensor "gates." In normal cells (HL-7702, human liver cells), the nanoplatform is able to entrap the loaded drugs, showing an "OFF" state; the nanoplatform is activated by endogenous miRNA-21 overexpressed in tumor cells (HepG2, human liver tumor cells), which serve as an exclusive key to unlock the nanoplatform through hybridization with programmable DNA hairpin, leading to a rapid drug release, showing an "ON" state. The nanoplatform exhibits high antitumor efficacy and low toxicity in in vitro and in vivo studies owing to its magnetic targeting and tumor cell-activated properties, paving the way for targeted and personalized tumor treatment and showing potential for clinical applications.

中文翻译：

通过特定分子识别和构象变化的“ OFF-ON”状态的磁性药物输送系统，用于精确的肿瘤治疗。

为了增强纳米药物递送系统的靶向肿瘤和特定肿瘤细胞的药物释放能力，开发了一种磁共振成像可追踪的磁性靶向纳米平台，并通过封盖介孔二氧化硅（MSN）涂层的铁制备了纳米平台。带有可编程DNA发夹传感器“门”的氧化物纳米粒子（IONP）。在正常细胞（HL-7702，人肝细胞）中，纳米平台能够截获负载的药物，呈“关闭”状态。纳米平台被在肿瘤细胞（HepG2，人肝肿瘤细胞）中过度表达的内源性miRNA-21激活，这是通过与可编程DNA发夹杂交来解锁纳米平台的专有密钥，从而导致药物快速释放，显示“ “ 状态。

更新日期：2020-02-06

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