Obesity is characterized by abnormal or excessive fat accumulation that impairs health. In this study, the effects of Spirulina lipids (SL) and fish oil (FO) on obesity and hepatic lipid accumulation in high-fat and high-sucrose diet induced obese C57BL/6J mice were evaluated and compared. After 12 weeks of feeding, 4% gamma-linolenic acid-enriched SL supplementation effectively reduced the gain of body weight, total white adipose tissue (WAT) weight and hepatic lipid levels in obese mice. Although dietary 4% FO also tended to suppress the increases of body weight and WAT weight in mice, no statistical difference was observed. The suppression of hepatic lipid accumulation by SL should be through regulating sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2-mediated triacylglycerol and cholesterol synthesis pathway as well as via enhancement of peroxisome proliferator-activated receptor alpha (PPAR α)-mediated β-oxidation. These findings firstly confirmed that SL could alleviate diet-induced obesity and hepatic lipid accumulation.

肥胖症的特征是异常或过多的脂肪蓄积会损害健康。在这项研究中，螺旋藻的作用评估并比较了高脂和高蔗糖饮食诱导的肥胖C57BL / 6J小鼠中肥胖（SL）和鱼油（FO）对肥胖和肝脂质蓄积的影响。喂养12周后，富含4％γ-亚麻酸的SL补充剂有效降低了肥胖小鼠的体重增加，总白色脂肪组织（WAT）重量和肝脂质水平。尽管饮食中4％FO还倾向于抑制小鼠体重和WAT体重的增加，但未观察到统计学差异。SL对肝脂质蓄积的抑制作用应通过调节固醇调节元件结合蛋白1c（SREBP-1c），SREBP-2介导的三酰甘油和胆固醇合成途径，以及通过过氧化物酶体增殖物激活受体α（PPARα ）介导的β-氧化作用。