Abstract The skin, as the largest and most accessible organ in the human body, contains biofluids rich in biomarkers useful not only in diagnosis and monitoring of diseases, but also in profiling an individual’s wellbeing. Advancements in micro- and nanotechnology research have underpinned the development of multifunctional wearable sensing devices. Those sensors may allow monitoring of physiological parameters from different skin sections such as epidermis, dermis and hypodermis by sampling various bodily fluids. Our review summarizes current advances in wearable biosensors for on-skin analysis of sweat, transdermal monitoring of interstitial fluid and analysis of subcutaneous fluids via implanted devices. The review is divided into three main parts describing biosensors acting on the different skin sections. Each part focuses on recent scientific and technological advancements in the wearable biosensing field by highlighting critical challenges as well as providing information on how these barriers are being addressed by the research community.

中文翻译：

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诊断游戏中的皮肤：用于医疗诊断的可穿戴生物传感器纳米和微系统

摘要 皮肤作为人体最大和最容易接近的器官，含有丰富的生物标志物，不仅可用于疾病的诊断和监测，还可用于分析个人的健康状况。微纳米技术研究的进步为多功能可穿戴传感设备的发展奠定了基础。这些传感器可以允许通过对各种体液取样来监测来自不同皮肤部分（例如表皮、真皮和皮下组织）的生理参数。我们的综述总结了可穿戴生物传感器在汗液皮肤分析、间质液透皮监测和通过植入装置分析皮下液方面的当前进展。该评论分为三个主要部分，描述作用于不同皮肤部分的生物传感器。