Simple β-O-4’ linked dimeric model compounds are often targeted as substrate to mimic the reactivity of lignin in enzymatic or chemical treatments. These models mimic the structure and reactivity of regular β-O-4′ linkages in lignin, but are less suitable to predict the reactivity of acylated β-O-4′ substructures, which are abundant in various types of lignin. Here, we present a one-step lipase-catalyzed acylation of a commercially available lignin model compound with p-coumaric acid, p-hydroxybenzoic acid, cinnamic acid and acetic acid as acyl donors. This facile procedure allows to obtain new and relevant lignin model compounds at milligram scale, with simple purification of products and unreacted substrate.

简单的β- O -4 '连接的二聚体模型化合物通常以底物为目标，以模拟木质素在酶或化学处理中的反应性。这些模型模拟了木质素中规则的β- O -4 '键的结构和反应性，但不太适合预测各种类型的木质素中丰富的酰化β- O -4 '亚结构的反应性。在这里，我们提出了对脂肪酶对p-香豆酸，p的木质素模型化合物的一步一步脂肪酶催化的酰化反应。-羟基苯甲酸，肉桂酸和乙酸作为酰基供体。这种简便的方法允许以毫克级获得新的和相关的木质素模型化合物，并且可以简单纯化产物和未反应的底物。