Our aim was to determine the association between objectively measured physical activity (PA) and bone strength of the distal limbs among older men. We studied 994 men from the MrOS cohort study (mean age 83.9) who had repeat (Year 7 and 14) 5-day activity assessment with at least 90% wear time (SenseWearPro3 Armband) and Year 14 measures using high resolution peripheral quantitative tomography (HR-pQCT) (Scanco). Total energy expenditure (TEE), total steps per day, peak cadence (mean of top 30 steps/min over 24 h) and time spent in a given level of activity: sedentary (reference, <1.5 metabolic equivalents of task [METs]), light (1.5 to <3 METs), or moderate to vigorous physical activity(MVPA: ≥3 METs) were calculated as mean over the two time points. Estimated failure load was determined from HR-pQCT data using finite element analysis. We used standardized variables and adjusted for potential confounders using linear regression. The means ±SDs for daily activity were: 2338 ± 356 kcal/d [TEE]; 5739 ± 2696 steps/day [step count], 60 ± 20 cpm [peak cadence], 67 ± 28 min/d [light activity], and 85 ± 52 min/d [MVPA]. Higher TEE, step count, and peak cadence were each associated with higher failure load of the distal radius (effect sizes respectively: 0.13 [95% CI: 0.05, 0.20], 0.11 [95% CI: 0.04, 0.18], and 0.08 [95% CI: 0.01, 0.15]) and higher failure load of the distal tibia (effect sizes respectively 0.21 [95% CI: 0.13, 0.28], 0.19 [95% CI: 0.13, 0.26], 0.19 [95% CI, 0.13, 0.25]). Time spent in MVPA vs. time sedentary was related to bone strength at both sites after adjustment, whereas time spent in light activity vs. time sedentary was not. TEE was associated with compartmental area and BMD parameters at distal tibia, but only area parameters at the distal radius. In summary, MVPA over a 7-year period of time may have a modest association with bone strength and geometry among older men.

中文翻译：

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中度至剧烈体力活动的客观测量与老年男性较高的远端肢体骨强度相关

我们的目的是确定客观测量的身体活动 (PA) 与老年男性远端肢体骨强度之间的关联。我们研究了来自 MrOS 队列研究的 994 名男性（平均年龄 83.9 岁），他们进行了重复（第 7 年和第 14 年）为期 5 天的活动评估，佩戴时间至少为 90%（SenseWearPro3 臂带）和第 14 年使用高分辨率外围定量断层扫描测量（ HR-pQCT) (Scanco)。总能量消耗 (TEE)、每天的总步数、峰值节奏（24 小时内前 30 步/分钟的平均值）和在给定活动水平上花费的时间：久坐（参考，<1.5 代谢当量的任务 [METs]） 、轻度（1.5 至 <3 METs）或中度至剧烈体力活动（MVPA：≥3 METs）计算为两个时间点的平均值。使用有限元分析从 HR-pQCT 数据确定估计的失效载荷。我们使用标准化变量并使用线性回归调整潜在的混杂因素。日常活动的平均值 ±SD 为：2338 ± 356 kcal/d [TEE]；5739 ± 2696 步/天 [步数]、60 ± 20 cpm [峰值节奏]、67 ± 28 分钟/天 [轻度活动] 和 85 ± 52 分钟/天 [MVPA]。较高的 TEE、步数和峰值节奏均与较高的桡骨远端故障负荷相关（效应大小分别为：0.13 [95% CI: 0.05, 0.20]、0.11 [95% CI: 0.04, 0.18] 和 0.08 [ 95% CI: 0.01, 0.15]) 和更高的胫骨远端失效载荷（效应大小分别为 0.21 [95% CI: 0.13, 0.28]、0.19 [95% CI: 0.13, 0.26]、0.19 [95% CI, 0.13 , 0.25])。在 MVPA 中花费的时间与久坐时间与调整后两个部位的骨强度有关，而在轻度活动中花费的时间与久坐时间无关。TEE 与胫骨远端的区室面积和 BMD 参数相关，但仅与桡骨远端的面积参数相关。总之，7 年的 MVPA 可能与老年男性的骨强度和几何形状有适度的相关性。