During development, cells coordinate to organize in coherent structures. Although it is now well established that physical forces are essential for implementing this coordination, the instructive roles of mechanical inputs are not clear. Here, we show that the replacement of the larval epithelia by the adult one in Drosophila demands the coordinated exchange of mechanical signals between two cell types, the histoblasts (adult precursors) organized in nests and the surrounding larval epidermal cells (LECs). An increasing stress gradient develops from the center of the nests toward the LECs as a result of the forces generated by histoblasts as they proliferate and by the LECs as they delaminate (push/pull coordination). This asymmetric radial coordination of expansive and contractile activities contributes to epithelial replacement. Our analyses support a model in which cell-cell mechanical communication is sufficient for the rearrangements that implement epithelial morphogenesis.

中文翻译：

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机械协调足以促进果蝇变态过程中的组织替换。


在发育过程中，细胞协调组织成连贯的结构。尽管现在已经明确物理力量对于实现这种协调至关重要，但机械输入的指导作用尚不清楚。在这里，我们表明，果蝇幼虫上皮被成虫上皮取代需要两种细胞类型之间机械信号的协调交换，即组织成巢的组织细胞（成虫前体细胞）和周围的幼虫表皮细胞（LEC）。由于组织细胞增殖时和 LEC 分层时产生的力（推/拉协调），应力梯度从巢中心向 LEC 发展。这种扩张和收缩活动的不对称径向协调有助于上皮替换。我们的分析支持一个模型，其中细胞间的机械通讯足以实现上皮形态发生的重排。