BACKGROUND Paragangliomas and pheochromocytomas are sympathetic or parasympathetic tumors derived from the paraganglia and the adrenal medulla, respectively. Paragangliomas and pheochromocytomas can be sporadic or familial, the latter frequently being multifocal and possibly due to succinate dehydrogenase complex genes mutations. In addition, 12% of sporadic paragangliomas are related to covered succinate dehydrogenase complex mutations. The importance of identifying succinate dehydrogenase complex mutations is related to the risk for these patients of developing multiple tumors, including non-endocrine ones, showing an aggressive clinical presentation. CASE PRESENTATION We report the case of a 45-year-old Caucasian man with an indolent mass in his neck. Ultrasound of his neck, magnetic resonance imaging, and 1,4,7,10-tetraazacyclododecane-N(I),N(II),N(III),N(IIII)-tetraacetic acid(D)-Phe(1)-thy(3)-octreotide (68Ga-DOTATOC) positron emission tomography-computed tomography and endocrine work-up were consistent with a carotid body paraganglioma with concomitant nodal enlargement in several body regions, which turned out to be a follicular lymphoma at histology. He was found to carry a germline Succinate dehydrogenase subunit B gene (SDHB) mutation. CONCLUSION It is crucial to look for a second malignancy in the case of a paraganglioma demonstrating succinate dehydrogenase complex germline mutations.

中文翻译：

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颈部副神经节瘤和滤泡性淋巴瘤：一例报道。

背景神经节旁瘤和嗜铬细胞瘤分别是源自神经节旁和肾上腺髓质的交感性或副交感性肿瘤。副神经节瘤和嗜铬细胞瘤可以是散发性或家族性的，后者通常是多灶性的，可能是由于琥珀酸脱氢酶复合基因突变引起的。此外，有12％的散发性神经节瘤瘤与所覆盖的琥珀酸脱氢酶复合物突变有关。鉴定琥珀酸脱氢酶复合物突变的重要性与这些患者发生多种肿瘤（包括非内分泌性肿瘤）的风险有关，表现出积极的临床表现。病例介绍我们报告一例45岁高加索人脖子上弥漫性肿块的病例。颈部超声，磁共振成像和1,4,7,10-四氮杂环十二烷-N（I），N（II），N（III），N（IIII）-四乙酸（D）-Phe（1）-thy（3）-奥曲肽（68Ga-DOTATOC）正电子发射断层扫描计算机断层扫描和内分泌检查是一致的颈动脉旁神经节瘤伴在多个身体部位伴有淋巴结肿大，在组织学上证实为滤泡性淋巴瘤。发现他携带种系琥珀酸脱氢酶亚基B基因（SDHB）突变。结论在副神经节瘤表现出琥珀酸脱氢酶复合种系突变的情况下，寻找第二次恶性肿瘤至关重要。在组织学上证明是滤泡性淋巴瘤。发现他携带种系琥珀酸脱氢酶亚基B基因（SDHB）突变。结论在副神经节瘤表现出琥珀酸脱氢酶复合种系突变的情况下，寻找第二次恶性肿瘤至关重要。在组织学上证明是滤泡性淋巴瘤。发现他携带种系琥珀酸脱氢酶亚基B基因（SDHB）突变。结论在副神经节瘤表现出琥珀酸脱氢酶复合种系突变的情况下，寻找第二次恶性肿瘤至关重要。