BACKGROUND A possible connection on vascular basis between impaired kidney function and cognitive dysfunction has been suggested in previous studies. Contradictory results regarding specific cognitive domains have been reported. The aim for this study was to investigate the association between kidney function and specific cognitive domains. METHODS In this cross-sectional design, data from the general population based cohort study "Good aging in Skåne" (GÅS) was used. The sample included 2931 subjects ages 60 to 93 randomly selected from the southern part of Sweden. Estimated glomerular filtration rate (eGFR) for both creatinine and cystatine C was calculated using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation. The subjects underwent a test battery of neuropsychological tests assessing global cognitive function, learning and memory, language, complex attention, executive function, perceptual motor and meta-memory. Adjustments were made for age, sex, education and country of origin. RESULTS After adjustment for demographic variables, impaired kidney function was associated with 0.41 points worse result in MMSE, 0.56 points worse result in recognition, 0.66 points worse result in word fluency, 0.45 points worse result in digit cancellation, 0.99 points worse result in pattern comparison, and 3.71 s longer time to finish TMT B-A. Associations to cognitive function was also noted for mildly impaired kidney function defined as eGFR 45- < 60 ml/min/1,73m2. No association was found between kidney function and meta-memory. CONCLUSIONS Impaired kidney function as well as the severity of impaired kidney function is associated with impairment in learning and memory, language, complex attention, executive function and global cognitive function, but not meta-memory.

中文翻译：

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在老年人群中，肾功能受损与较低的认知功能有关。斯科讷（GÅS）队列研究的结果。

背景技术在先前的研究中已经提出了在血管基础上肾功能受损和认知功能障碍之间的可能联系。关于特定认知领域的矛盾结果已有报道。这项研究的目的是调查肾功能与特定认知领域之间的关联。方法在此横断面设计中，使用了基于一般人群的队列研究“斯科讷的良好衰老”（GÅS）中的数据。该样本包括从瑞典南部随机抽取的2931名年龄在60至93岁之间的受试者。肌酐和半胱氨酸C的估计肾小球滤过率（eGFR）使用慢性肾脏病流行病学协作（CKD-EPI）公式计算。受试者接受了一系列神经心理学测试，以评估整体认知功能，学习和记忆，语言，复杂注意力，执行功能，知觉运动和元记忆。对年龄，性别，教育程度和原籍国进行了调整。结果调整了人口统计学变量后，肾功能受损与MMSE下降0.41分，识别能力下降0.56分，英语流利程度下降0.66分，数字消除效果下降0.45分，模式比较下降0.99分有关，而完成TMT BA的时间则延长了3.71 s。还发现肾功能轻度受损与认知功能相关，定义为eGFR 45- <60 ml / min / 1,73m2。在肾功能和元记忆之间未发现关联。