The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo. Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural changes are prerequisites for establishing transient uterine receptivity for embryo implantation. Vesicle trafficking in the LE and receptor-mediated paracrine and autocrine mechanisms are crucial both for LE preparation and LE communications with the embryo and stroma during the initiation of embryo implantation. This review mainly covers recent in vivo studies in LE of mouse models from 0.5 days post-coitus (D0.5) to ∼D4 20 h when the trophoblasts pass through the LE layer for embryo implantation. The review is organized into three interconnected sections: preimplantation LE preparation for embryo attachment, embryo-LE communications, and LE-stroma communications.

中文翻译：

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子宫腔上皮作为胚胎植入的瞬时通道

子宫腔上皮 (LE) 是植入胚胎的第一个母体接触。宫内液体吸收、LE 增殖和细胞凋亡的停止以及 LE 结构变化是建立短暂子宫接受胚胎植入的先决条件。LE 中的囊泡运输和受体介导的旁分泌和自分泌机制对于 LE 准备和 LE 在胚胎植入开始期间与胚胎和基质的通信都至关重要。本综述主要涵盖最近在 LE 小鼠模型中的体内研究，从性交后 0.5 天（D0.5）到~D4 20 小时，当滋养细胞通过 LE 层进行胚胎植入时。该评论分为三个相互关联的部分：胚胎附着的植入前 LE 准备、胚胎-LE 通信和 LE-基质通信。