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Transition Metal-free Direct C-H Trifluoromethyltion of (Hetero)arenes with Togni’s Reagent
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2019-12-19 , DOI: 10.1016/j.tetlet.2019.151538
Xiaoyu Chen , Licheng Ding , Linlin Li , Jingya Li , Dapeng Zou , Yangjie Wu , Yusheng Wu

A new transition-metal-free direct C−H trifluoromethylation reaction of (hetero)arenes with Togni’s reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.



中文翻译:

用Togni试剂进行(杂)芳烃的无过渡金属的直接CH三氟甲基化

开发了一种新的无杂芳烃与Togni's试剂的无过渡金属直接C-H三氟甲基化反应。该转化在温和条件下平稳进行,并且表现出对许多合成相关官能团的良好耐受性。它为合成三氟甲基化(杂)芳烃提供了另一种方法。

更新日期:2019-12-20
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