A simple and efficient copper-catalyzed aminooxygenation of unactivated alkenes with commercially available (2,2,6,6-tetramethylpiperidin-1-yl)-oxyl (TEMPO) as an oxygen source is reported. With this protocol, a variety of functionalized pyrrolidones were obtained in good to excellent yields, and good tolerance of functional groups and broad substrate scope were observed. Notably, the N-cyclization step selectively proceeded in an exo manner, and this protocol provides an efficient and straightforward approach to prepare vicinal amino alcohols.

中文翻译：

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通过铜催化的未活化烯烃的氨基氧化作用获得功能化的吡咯烷酮

据报道，以市售的（2,2,6,6-四甲基哌啶-1-基）-氧基（TEMPO）作为氧源，对未活化的烯烃进行了简单而有效的铜催化的氨基氧化。通过该协议，可以以良好的产率获得各种功能化的吡咯烷酮，并观察到对官能团的良好耐受性和广泛的底物范围。值得注意的是，N-环化步骤以外切方式选择性地进行，并且该方案提供了制备邻位氨基醇的有效且直接的方法。