当前位置：
X-MOL 学术
›
J. Appl. Polym. Sci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Retentive drug delivery systems based on shape memory materials
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2019-12-20 , DOI: 10.1002/app.48798 Alessandra Maroni 1 , Alice Melocchi 1 , Lucia Zema 1 , Anastasia Foppoli 1 , Andrea Gazzaniga 1
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2019-12-20 , DOI: 10.1002/app.48798 Alessandra Maroni 1 , Alice Melocchi 1 , Lucia Zema 1 , Anastasia Foppoli 1 , Andrea Gazzaniga 1
Affiliation
|
Retentive drug delivery systems are intended for prolonged residence and release inside hollow organs of the body, in pursuit of either local or systemic therapeutic goals. Because of the relatively long‐lasting period of time they could cover during operation, a primary advantage arising from their use would lie in reduced dosing frequency, thereby improving the overall adherence of patients to prescribed medication regimens. The treatment of numerous pathologies that affect the urinary bladder and the stomach could especially benefit from viability of such delivery technologies. Moreover, by making use of effective gastroretentive dosage forms, the bioavailability of drugs that are preferably absorbed from the upper gastrointestinal tract could be increased. Expansion of devices following administration is often exploited for retention purposes, and several formulation strategies have been proposed in this respect. Innovative applications of shape memory materials have also been explored, highlighting the great inherent potential for facing the challenges involved. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48798.
中文翻译：
基于形状记忆材料的保持性药物输送系统
保持性药物输送系统旨在延长体内中空器官的停留和释放，以实现局部或全身性治疗目标。由于它们在手术期间可以覆盖相对较长的时间，因此使用它们的主要优势在于降低了给药频率，从而提高了患者对处方药治疗方案的总体依从性。影响膀胱和胃的多种病理的治疗可特别受益于这种递送技术的可行性。此外，通过使用有效的胃滞留剂型，可以增加优选从上消化道吸收的药物的生物利用度。在管理后扩展设备通常是出于保留目的，在这方面已经提出了几种配方策略。还探索了形状记忆材料的创新应用，突显了应对所面临挑战的巨大内在潜力。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学2020，137，48798。
更新日期：2020-03-26
中文翻译：
基于形状记忆材料的保持性药物输送系统
保持性药物输送系统旨在延长体内中空器官的停留和释放，以实现局部或全身性治疗目标。由于它们在手术期间可以覆盖相对较长的时间，因此使用它们的主要优势在于降低了给药频率，从而提高了患者对处方药治疗方案的总体依从性。影响膀胱和胃的多种病理的治疗可特别受益于这种递送技术的可行性。此外，通过使用有效的胃滞留剂型，可以增加优选从上消化道吸收的药物的生物利用度。在管理后扩展设备通常是出于保留目的，在这方面已经提出了几种配方策略。还探索了形状记忆材料的创新应用，突显了应对所面临挑战的巨大内在潜力。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学2020，137，48798。
京公网安备 11010802027423号