A highly atroposelective (up to 97 % ee) Au-catalyzed synthesis of 1,1'-binaphthalene-2,3'-diols is reported starting from a range of substituted benzyl alkynones. Essential for the achievement of high enantioselectivity during the key assembly of the naphto-3-ol unit is the use of TADDOL-derived α-cationic phosphonites as ancillary ligands. Preliminary results demonstrate that the transformation of the obtained binaphthyls into axially chiral monodentate phosphines is possible without degradation of enantiopurity.

中文翻译：

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金催化的1,1'-双萘-2,3'-二醇的阻转选择性合成。

据报道，从一系列取代的苄基炔烃开始，具有高度的对映选择性（高达97％ee）的Au催化的Au催化1,1'-联萘-2,3'-二醇的合成。在萘-3-醇单元的关键组装过程中实现高对映选择性的关键是使用TADDOL衍生的α-阳离子亚膦酸酯作为辅助配体。初步结果表明，所获得的联萘可以转化为轴向手性单齿膦，而不会降低对映体纯度。