Highly dispersed aggregation-free gold nanoparticles intercalated into the walls of mesoporous silica (AuMS) were synthesized using thioether-functionalized silica as a nanozyme, which exhibited an excellent peroxidase mimic activity. The AuMS material was characterized via XRD, N₂ adsorption–desorption, FESEM, SEM-EDS particle mapping, TEM, and XPS. The peroxidase-like activity of the AuMS material was studied thoroughly, and the effect of pH and temperature was evaluated. The reproducibility of the peroxidase mimic activity and long-term stability of the AuMS catalyst were also studied. Furthermore, the AuMS catalyst was successfully utilized for the detection and quantification of dopamine, an important neurotransmitter, colorimetrically with a linear range of 10–80 μM and a limit of detection (LOD) value of 1.28 nM. The determination of dopamine concentration in commercially available dopamine hydrochloride injection showed high accuracy, good reproducibility, and high selectivity in the presence of uric acid, ascorbic acid, glucose, tryptophan, phenylalanine, and tyrosine.

中文翻译：

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一种用于选择性比色检测多巴胺的金纳米颗粒插层介孔二氧化硅纳米酶

使用硫醚官能化二氧化硅作为纳米酶合成了嵌入介孔二氧化硅（AuMS）壁中的高度分散的无聚集金纳米粒子，该纳米粒子表现出优异的过氧化物酶模拟活性。AuMS材料通过XRD、N _2表征吸附-解吸、FESEM、SEM-EDS 粒子映射、TEM 和 XPS。深入研究了AuMS材料的类过氧化物酶活性，并评估了pH和温度的影响。还研究了过氧化物酶模拟活性的重现性和 AuMS 催化剂的长期稳定性。此外，AuMS 催化剂成功地用于检测和定量多巴胺（一种重要的神经递质），其比色线性范围为 10-80 μM，检测限 (LOD) 值为 1.28 nM。在尿酸、抗坏血酸、葡萄糖、色氨酸、苯丙氨酸和酪氨酸的存在下，市售的盐酸多巴胺注射液中多巴胺浓度的测定显示出准确度高、重现性好、选择性高的特点。