Synthesis of 2,3,4-trisubstituted pyrrole derivatives via [3 + 2] cyclization of activated methylene isocyanides with 4-(arylidene)-2-substituted oxazol-5(4H)-ones,Organic Chemistry Frontiers

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Synthesis of 2,3,4-trisubstituted pyrrole derivatives via [3 + 2] cyclization of activated methylene isocyanides with 4-(arylidene)-2-substituted oxazol-5(4H)-ones
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2019/12/19 , DOI: 10.1039/c9qo01044k
Jing Zhang _{1,

2,

3,

4,

5} , Man Liu _{4,

5,

6,

7,

8} , Chao Li _{4,

5,

6,

7,

8} , Yan-Jun Xu _{1,

2,

3,

4} , Lin Dong _{4,

5,

6,

7,

8}

Affiliation

An efficient base-catalyzed [3 + 2] cyclization between isocyanides and 4-(arylidene)-2-substituted oxazol-5(4H)-ones has been successfully developed to form 2,3,4-trisubstituted and 2,2,3,4-tetrasubstituted pyrrole derivatives. This transition metal free reaction occurs at room temperature under environmentally friendly conditions, tolerating water and air.

中文翻译：

通过[3 + 2]与4-（亚芳基）-2-取代的恶唑-5（4H）-的活化亚甲基异氰酸酯的环化反应合成2,3,4-三取代的吡咯衍生物

已成功开发出异氰酸酯与4-（亚芳基）-2-取代的恶唑-5（4 H）-酮之间有效的碱催化[3 + 2]环化反应，形成2,3,4-三取代和2,2， 3，4-四取代的吡咯衍生物。这种无过渡金属的反应在室温，环境友好的条件下发生，可以耐受水和空气。

更新日期：2020-02-13

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