In 2013, the World Health Organization (WHO) recommended initiating combination ART (cART) in all adults with HIV and CD4+ lymphocyte counts (CD4) <500 cells/mm3. In 2015, this was updated to recommend cART initiation in all patients with HIV, regardless of CD4 count. Implementation of these guidelines in real‐world settings has not been evaluated in Latin America. To assess changes in time to cART initiation during routine care, we estimated trends in time from enrolment in care to cART initiation in HIV‐positive adults with high CD4 counts in the Caribbean, Central and South America network for HIV Epidemiology (CCASAnet) during 2003 to 2017.

中文翻译：

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拉丁美洲 CD4 计数高的成年人开始 ART 的时间变化：一项队列研究

2013 年，世界卫生组织 (WHO) 建议对所有 HIV 感染且 CD4+ 淋巴细胞计数 (CD4) <500 个细胞/mm3 的成人开始联合 ART (cART)。2015 年，该指南更新为建议所有 HIV 患者开始 cART，无论 CD4 计数如何。拉丁美洲尚未评估这些指南在现实环境中的实施情况。为了评估常规护理期间开始 cART 的时间变化，我们估计了 2003 年加勒比、中美洲和南美洲 HIV 流行病学网络 (CCASAnet) 中 CD4 计数高的 HIV 阳性成人从护理入组到开始 cART 的时间趋势到2017年。