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Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency
Journal of the International AIDS Society ( IF 4.6 ) Pub Date : 2019-12-01 , DOI: 10.1002/jia2.25425 Youry Kim 1, 2 , Paul U Cameron 2, 3 , Sharon R Lewin 2, 3 , Jenny L Anderson 2
Journal of the International AIDS Society ( IF 4.6 ) Pub Date : 2019-12-01 , DOI: 10.1002/jia2.25425 Youry Kim 1, 2 , Paul U Cameron 2, 3 , Sharon R Lewin 2, 3 , Jenny L Anderson 2
Affiliation
HIV latency can be established in vitro following direct infection of a resting CD4+ T cell (pre‐activation latency) or infection of an activated CD4+ T cell which then returns to a resting state (post‐activation latency). We modified a previously published dual‐fluorescent reporter virus seeking to track the establishment and reactivation of pre‐activation latency in primary CD4+ T cells.
中文翻译:
双荧光 HIV 报告病毒在预激活潜伏期模型中的局限性
HIV潜伏期可以在直接感染静息CD4+ T细胞(激活前潜伏期)或感染激活的CD4+ T细胞后返回静息状态(激活后潜伏期)后在体外建立。我们修改了之前发表的双荧光报告病毒,试图追踪原代 CD4+ T 细胞中预激活潜伏期的建立和重新激活。
更新日期:2019-12-01
中文翻译:
双荧光 HIV 报告病毒在预激活潜伏期模型中的局限性
HIV潜伏期可以在直接感染静息CD4+ T细胞(激活前潜伏期)或感染激活的CD4+ T细胞后返回静息状态(激活后潜伏期)后在体外建立。我们修改了之前发表的双荧光报告病毒,试图追踪原代 CD4+ T 细胞中预激活潜伏期的建立和重新激活。