The Dutch colorectal cancer (CRC) screening program started in 2014, inviting the target population biennially to perform a fecal immunochemical test (FIT). We obtained prospectively collected data from the national screening information‐system to present the results of the second round (2016) and evaluate the impact of increasing the FIT cut‐off halfway through the first round from 15 to 47 μg Hb/g feces on outcomes in the second round. Second round screening was done with a 47 μg Hb/g feces FIT cut‐off. Participants were classified based on first round participation status as either FIT (15,47) or FIT (47,47) participants, and previous nonparticipants. In total, 348,891 (75.9%) out of 459,740 invitees participated in the second round. Participation rates were 93.4% among previous participants and 21.0% among previous non‐participants. FIT(47,47) participants had a significantly higher detection rate of AN (15.3 vs. 10.4 per 1,000 participants) compared to FIT(15,47) participants in the second round, while their cumulative detection rate of AN over two rounds was significantly lower (45.6 vs. 52.6 per 1,000 participants). Our results showed that participation in the Dutch CRC screening program was consistently high and that second round detection rates depended on the first round FIT cut‐off. The cumulative detection over two rounds was higher among FIT(15,47) participants. These findings suggest that a substantial part of, but not all the missed findings in the first round due to the increased FIT cut‐off were detected in the subsequent round.

中文翻译：

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荷兰大肠癌筛查计划的第二轮：粪便免疫化学检测截止水平的提高对筛查产量的影响。

荷兰大肠癌（CRC）筛查计划于2014年启动，每两年邀请目标人群进行一次粪便免疫化学测试（FIT）。我们从国家筛查信息系统中获得了前瞻性收集的数据，以介绍第二轮（2016年）的结果，并评估了将第一轮中途的FIT临界浓度从15μgHb / g粪便增加到结果的影响在第二轮。第二轮筛查以47μgHb / g粪便FIT临界值进行。根据第一轮参与状态将参加者分为FIT（15,47）或FIT（47,47）参加者，以及以前的非参加者。总共459,740名受邀者中有348,891名（75.9％）参加了第二轮。以前的参与者的参与率为93.4％，以前的非参与者的参与率为21.0％。散客（47，与第二轮的FIT（15,47）参与者相比，每千人中10.4人），而他们在两轮中对AN的累计检测率明显更低（每千人中45.6人对52.6人）。我们的结果表明，参与荷兰CRC筛查计划的人数一直很高，第二轮检出率取决于第一轮FIT的截止时间。FIT（15,47）参与者中两轮的累积检出率更高。这些发现表明，由于下一轮FIT截止值的增加，在第一轮中有相当一部分（但不是全部）遗漏了发现。