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Prospective of nanoscale metal organic frameworks [NMOFs] for cancer therapy.
Seminars in Cancer Biology ( IF 12.1 ) Pub Date : 2019-12-19 , DOI: 10.1016/j.semcancer.2019.12.015
Mohammed Razeeth Shait Mohammed 1 , Varish Ahmad 2 , Abrar Ahmad 1 , Shams Tabrez 3 , Hani Choudhry 4 , Mazin A Zamzami 4 , Muhammed A Bakhrebah 5 , Aftab Ahmad 2 , Samina Wasi 6 , Hasan Mukhtar 7 , Mohammad Imran Khan 4
Affiliation  

Nano metal organic frameworks (NMOFs) belong to the group of nanoporous materials. Over the decades, the conducted researches explored the area for the potential applications of NMOFs in areas like biomedical, chemical engineering and materials science. Recently, NMOFs have been explored for their potential use in cancer diagnosis and therapeutics. The excellent physico-chemical features of NMOFs also make them a potential candiadate to facilitate drug design, delivery and storage against cancer cells. In this review, we have explored the characterstic features, synthesis methods, NMOFs based drug delivery, diagnosis and imaging in various cancer types. In addition to this, we have also pondered on the stability and toxicological concerns of NMOFs. Despite, a significant research has been done for the potential use of NMOFs in cancer diagonostic and therapeutics, more information regarding the stability, in-vivo clearance, toxicology, and pharmacokinetics is still needed to ehnace the use of NMOFs in cancer diagonostic and therapeutics.

中文翻译:

用于癌症治疗的纳米级金属有机框架 [NMOFs] 的前景。

纳米金属有机骨架(NMOFs)属于纳米多孔材料组。几十年来,所进行的研究探索了 NMOF 在生物医学、化学工程和材料科学等领域的潜在应用。最近,已经探索了 NMOF 在癌症诊断和治疗中的潜在用途。NMOF 优异的物理化学特性也使它们成为促进针对癌细胞的药物设计、递送和储存的潜在候选者。在这篇综述中,我们探讨了各种癌症类型的特征、合成方法、基于 NMOF 的药物递送、诊断和成像。除此之外,我们还思考了 NMOF 的稳定性和毒理学问题。尽管,
更新日期:2019-12-19
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