Undifferentiated sarcoma of soft tissue (USTS) are aggressive sarcomas that remain a diagnosis of exclusion and show extreme genomic complexity. Many advances in diagnostic criteria have resulted in several revisions in the definition of this rare cancer type. Recent sequencing efforts have illuminated the nature of the genome complexity and have revealed extensive copy number heterogeneity and multiple evolutionary patterns of development. This review places these recent advances into their historical and translational context and covers the changes in nomenclature, molecular classification, and the promise of personalised medicine.

中文翻译：

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软组织未分化肉瘤的基因组学：进展，挑战和机遇。

软组织未分化肉瘤（USTS）是侵袭性肉瘤，仍被诊断为排斥并显示出极端的基因组复杂性。诊断标准的许多进步导致对这种罕见癌症类型的定义进行了多次修订。最近的测序工作阐明了基因组复杂性的本质，并揭示了广泛的拷贝数异质性和多种进化发育模式。本文将这些最新进展纳入其历史和翻译背景，并涵盖了命名法，分子分类和个性化医学前景的变化。