Convergent genomic signatures of high-altitude adaptation among domestic mammals,National Science Review

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Convergent genomic signatures of high-altitude adaptation among domestic mammals
National Science Review ( IF 20.6 ) Pub Date : 2019-12-19 , DOI: 10.1093/nsr/nwz213
Dong-Dong Wu ₁ , Cui-Ping Yang ₂ , Ming-Shan Wang ₁ , Kun-Zhe Dong ₃ , Da-Wei Yan ₄ , Zi-Qian Hao ₅ , Song-Qing Fan ₆ , Shu-Zhou Chu ₆ , Qiu-Shuo Shen ₂ , Li-Ping Jiang ₂ , Yan Li ₇ , Lin Zeng ₁ , He-Qun Liu ₁ , Hai-Bing Xie ₁ , Yun-Fei Ma ₁ , Xiao-Yan Kong ₄ , Shu-Li Yang ₄ , Xin-Xing Dong ₄ , Ali Esmailizadeh ₈ , David M Irwin ₁ , Xiao Xiao ₂ , Ming Li ₂ , Yang Dong ₁ , Wen Wang ₁ , Peng Shi ₁ , Hai-Peng Li ₉ , Yue-Hui Ma ₃ , Xiao Gou ₄ , Yong-Bin Chen ₂ , Ya-Ping Zhang ₁

Affiliation

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Key Laboratory of Animal Nutrition and Feed Science of Yunnan Province, Yunnan Agricultural University, Kunming 650201, China.
CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
State Key Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China.
Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, PB 76169-133, Iran.
Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China.

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.

更新日期：2019-12-19

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