Changes of serum interleukin-6 in healthy pregnant women and establishment of relevant reference intervals.,Clinica Chimica Acta

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Changes of serum interleukin-6 in healthy pregnant women and establishment of relevant reference intervals.
Clinica Chimica Acta ( IF 3.2 ) Pub Date : 2019-12-19 , DOI: 10.1016/j.cca.2019.12.013
Yaoyang Fu ₁ , Lingli Tang ₁ , Min Hu ₁ , Zhongyuan Xiang ₁ , Yun Hu ₂

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OBJECTIVE To explore the changes of serum interleukin-6 (IL-6) levels in healthy pregnant women and establish reference intervals (RIs). METHOD According to the requirements for the RIs study model and the reference population screening criteria in C28-A3 document, Serum IL-6 levels were measured by electrochemiluminescence immunoassay in 480 healthy Chinese women, including 120 pregnant women in each of the first, second and third trimester and 120 non-pregnant women as the negative control. The establishment of RIs for IL-6 were defined using nonparametric percentile. RESULTS The RIs for serum IL-6 levels in healthy pregnant women is <4.19 pg/ml, the RIs for serum IL-6 levels in healthy pregnant women who are in the first trimester is <3.52 pg/ml, and the RIs for serum IL-6 levels in healthy pregnant women who are in the second and third trimester is <4.40 pg/ml. CONCLUSIONS Serum IL-6 level in healthy pregnant women is higher than the healthy non-pregnant women, and the level of IL-6 who are in the second and third trimester is higher than those in the first. This paper successfully established RIs for serum IL-6 levels in pregnant women, providing a reference for clinical medical staff and laboratory workers.

更新日期：2019-12-19

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