A mild method for the aminolysis of lactones with aminoheterocycles in the presence of magnesium ethoxide is described. A wide range of electronically diverse aminoheterocycles and substituted lactones successfully participate in this transformation to furnish the resulting amido-alcohol products. Further application of this method to the synthesis of chiral α-amino amides derivatives is also described.

中文翻译：

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乙醇镁介导的氨基杂环内酯氨基分解

描述了在乙醇镁存在下用氨基杂环对内酯进行氨解的温和方法。各种各样的电子多样性的氨基杂环和取代的内酯成功地参与了这一转变，从而提供了最终的酰胺醇产品。还描述了该方法在合成手性α-氨基酰胺衍生物中的进一步应用。