We present a comparative study of the toxicity of polyethylene glycol (PEG)-coated cobalt ferrite nanoparticles and nanospheres. Nanoparticles were prepared by hydrothermal method while nanospheres were prepared by solvothermal technique. The surface of nanomaterials was successfully modified with polyethylene glycol. To investigate the morphology of the prepared samples, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, thermogravimetric analysis (TGA), and electron microscopy techniques were employed. Structural analyses confirmed the formation of polycrystalline cobalt ferrite nanoparticles with diameters in the range 20-25 nm and nanospheres in the range 80-100 nm, respectively. Kunming SPF mice (female, 6-8 weeks old) were used to investigate the toxicity induced by cobalt ferrite nanoparticles and nanospheres in different organs of the mice. Biodistribution studies, biochemical indices, histopathological assessments, inflammatory factors, oxidation and antioxidant levels, and cytotoxicity tests were performed to assess the toxicity induced by cobalt ferrite nanoparticles and nanospheres in mice. Cobalt ferrite nanospheres were found to be more toxic than the nanoparticles and curcumin was proved to be a good healing agent for the toxicity induced by PEG-coated cobalt ferrite nanomaterials in mice.

中文翻译：

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聚乙二醇包覆的钴铁氧体纳米球和纳米粒子毒性的比较研究。

我们目前对聚乙二醇（PEG）涂层的钴铁氧体纳米颗粒和纳米球的毒性进行比较研究。水热法制备纳米粒子，溶剂热法制备纳米球。纳米材料的表面已成功地用聚乙二醇修饰。为了研究所制备样品的形态，采用了X射线衍射（XRD），傅立叶变换红外（FTIR）光谱，拉曼光谱，热重分析（TGA）和电子显微镜技术。结构分析证实形成了直径分别在20-25 nm范围内的纳米球和80-100 nm范围内的纳米球的多晶钴铁氧体纳米颗粒。昆明SPF小鼠（雌性，6-8周大）用于研究钴铁氧体纳米颗粒和纳米球在小鼠不同器官中引起的毒性。进行了生物分布研究，生化指标，组织病理学评估，炎症因子，氧化和抗氧化剂水平以及细胞毒性试验，以评估钴铁氧体纳米颗粒和纳米球对小鼠的诱导毒性。发现钴铁氧体纳米球比纳米粒子毒性更高，姜黄素被证明是由PEG包覆的钴铁氧体纳米材料在小鼠中诱导的毒性的良好治愈剂。进行了细胞毒性试验，以评估钴铁氧体纳米颗粒和纳米球在小鼠中诱导的毒性。发现钴铁氧体纳米球比纳米粒子毒性更高，姜黄素被证明是由PEG包覆的钴铁氧体纳米材料在小鼠中诱导的毒性的良好治愈剂。进行了细胞毒性试验，以评估钴铁氧体纳米颗粒和纳米球在小鼠中诱导的毒性。发现钴铁氧体纳米球比纳米粒子毒性更高，姜黄素被证明是由PEG包覆的钴铁氧体纳米材料在小鼠中诱导的毒性的良好治愈剂。