Recent studies have demonstrated that long non-coding RNAs (lncRNAs) play critical roles in cancer development and progression. However, the mechanism by which lncRNAs contribute to colorectal cancer remains unclear. In this study, we identified the lncRNA, DANCR, which was upregulated in colorectal cancer. The upregulation of DANCR expression was associated with shorter patient survival time. DANCR depletion decreased cell proliferation, cell cycle progression, and tumorigenesis in a subcutaneous mouse xenograft model system. We further demonstrated that DANCR bound with lysine acetyltransferase 6A. This binding was essential for KAT6A acetyltransferase activity and thus, it influenced the expression of KAT6A target genes. Our data indicated that DANCR functions as an oncogenic lncRNA that promotes tumor development and progression. Therefore, DANCR may be a target molecule for colorectal cancer treatment.

中文翻译：

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长的非编码RNA DANCR通过与赖氨酸乙酰转移酶6A结合来促进结直肠肿瘤的生长。

最近的研究表明，长的非编码RNA（lncRNA）在癌症的发展和进程中起着至关重要的作用。然而，lncRNA促成大肠癌的机制仍不清楚。在这项研究中，我们鉴定了在结肠直肠癌中上调的lncRNA，DANCR。DANCR表达的上调与较短的患者存活时间有关。DANCR消耗减少了皮下小鼠异种移植模型系统中的细胞增殖，细胞周期进程和肿瘤发生。我们进一步证明了DANCR与赖氨酸乙酰基转移酶6A结合。这种结合对于KAT6A乙酰转移酶的活性是必不可少的，因此，它影响了KAT6A靶基因的表达。我们的数据表明，DANCR作为促进肿瘤发生和发展的致癌lncRNA。所以，